Research Centre in Epidemiology and Preventive Medicine - EPIMED, Department of Clinical and Experimental Medicine, University of Insubria, Via O Rossi 9, 21100 Varese, Italy. Research Centre in Epidemiology and Preventive Medicine - EPIMED, Department of Clinical and Experimental Medicine, University of Insubria, Via O Rossi 9, 21100 Varese, Italy; Research Centre on Dyslipidemia, Department of Clinical and Experimental Medicine, University of Insubria, Viale Borri 57, 21100 Varese, Italy. Department of Biostatistics, University of North Carolina at Chapel Hill, 137 E Franklin Street, Chapel Hill, NC 27514, USA. Department of Health Sciences, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milano, Italy. IRCCS Istituto Auxologico Italiano, University of Milano-Bicocca, Milano, Italy. Research Centre in Epidemiology and Preventive Medicine - EPIMED, Department of Clinical and Experimental Medicine, University of Insubria, Via O Rossi 9, 21100 Varese, Italy. Electronic address: marco.ferrario@uninsubria.it.